I suppose you could do this with the Ad Hoc Do Box (bottom field of the Run Window). You can run your scripts by typing the name of your script and specifying the arguments after the script name.
I suppose you could create a temp script that invokes your other script with the appropriate arguments. You could then do an option+run selection or run script to activate the debugger, but all breakpoints and pausescript commands are ignored if you run a script through the AHDB. This was intentional by design but could change in the future.