I find myself changing the desktop resolution of the SUT on occasion. I have dealt with software that deals with this specifically. Each time this is done, Eggplant fails because it cannot locate images captured on, for example, a 800x00 screen that you are currently running at 1024x768.
I think this could be resolved if a new Eggplant search method were added. It would work by searching for ratios of neighboring pixels. So, even if you change resolutions, the ratios would be the same.
I hope this made sense.